Typhoid fever was previously considered a typical disease of school children and adolescents however, most recent epidemiologic data from India, Pakistan, Bangladesh and Vietnam clearly show that younger children are also highly affected by typhoid fever and are at risk of severe disease –. Typhi related morbidity and mortality are reported. Although endemic in many developing countries, typhoid fever has the highest incidence in the Indian subcontinent where 90% of the S. Typhi), represents a global public health issue causing over 21 million cases of disease and over 200,000 deaths per year worldwide. Typhoid fever, a disease caused by Salmonella enterica serovar Typhi ( S. PvD, FK and IDC are all employees of Univeristy of Antwerp, Belgium. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. AS and AP receive stock options from Novartis. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: AA, VB, AKH, SR, FM, RMQK, EM, VDC, AS, LBM, AP are all Novartis employees. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was conducted in collaboration with Sclavo Vaccines Association with grants from Regione Toscana and Fondazione Monte Dei Paschi di Siena which partially funded the trials. Received: JAccepted: SeptemPublished: September 30, 2011Ĭopyright: © 2011 van Damme et al. PLoS ONE 6(9):Įditor: Ray Borrow, Health Protection Agency, United Kingdom (2011) Safety, Immunogenicity and Dose Ranging of a New Vi-CRM 197 Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults. Citation: van Damme P, Kafeja F, Anemona A, Basile V, Hilbert AK, De Coster I, et al.
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